生物
密螺旋体
细胞凋亡
PI3K/AKT/mTOR通路
MAPK/ERK通路
蛋白激酶B
细胞生物学
细菌外膜
信号转导
先天免疫系统
免疫学
免疫系统
梅毒
生物化学
基因
大肠杆菌
人类免疫缺陷病毒(HIV)
作者
Weiwei Li,Sijia Li,Jianye Wang,Maoying Yu,Hongyu Yang,Zhangping He,Yuanyuan Tang,Jie Liu,Ningyuan Guo,Dong‐De Xie,Zhaoping Liu,Kang Zheng,Man Xu,Yimou Wu
摘要
Abstract Syphilis is a persistent sexually transmitted disease caused by infiltration of the elusive pathogen Treponema pallidum . Despite the prevalence of human polymorphonuclear neutrophils (hPMNs) within cutaneous lesions, which are characteristic of incipient syphilis, their role in T. pallidum infection remains unclear. Tp92 is the only T. pallidum helical outer membrane protein that exhibits structural features similar to those of outer membrane proteins in other gram‐negative bacteria. However, the functional mechanism of this protein in immune cells remains unclear. Neutrophils are short‐lived cells that undergo innate apoptosis in response to external stimuli that typically influence this process. In this study, we determined that Tp92 impedes the activation of procaspase‐3 via the ERK MAPK, PI3K/Akt, and NF‐κB signaling pathways, consequently suppressing caspase‐3 activity within hPMNs, and thereby preventing hPMNs apoptosis. Furthermore, Tp92 could also modulate hPMNs apoptosis by enhancing the expression of the anti‐apoptotic protein Mcl‐1, stimulating IL‐8 secretion, and preserving the mitochondrial membrane potential. These findings provide valuable insights into the molecular mechanisms underlying T. pallidum infection and suggest potential therapeutic targets for syphilis treatment.
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