肾素-血管紧张素系统
内分泌系统
免疫系统
生物
多样性(控制论)
神经科学
医学
血压
生物信息学
内分泌学
免疫学
激素
计算机科学
人工智能
作者
Adithi Rao,Shabir Ahmad Bhat,Tomohiro Shibata,Jorge F. Giani,Florian Rader,Kenneth E. Bernstein,Zakir Khan
摘要
Abstract The renin‐angiotensin system (RAS) has been widely known as a circulating endocrine system involved in the control of blood pressure. However, components of RAS have been found to be localized in rather unexpected sites in the body including the kidneys, brain, bone marrow, immune cells, and reproductive system. These discoveries have led to steady, growing evidence of the existence of independent tissue RAS specific to several parts of the body. It is important to understand how RAS regulates these systems for a variety of reasons: It gives a better overall picture of human physiology, helps to understand and mitigate the unintended consequences of RAS‐inhibiting or activating drugs, and sets the stage for potential new therapies for a variety of ailments. This review fulfills the need for an updated overview of knowledge about local tissue RAS in several bodily systems, including their components, functions, and medical implications.
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