炎症
骨关节炎
关节炎
聚乙烯亚胺
调解人
软骨
介孔二氧化硅
氧化应激
癌症研究
材料科学
软骨细胞
滑液
医学
药理学
介孔材料
化学
免疫学
内科学
病理
生物化学
转染
替代医学
解剖
基因
催化作用
作者
Tongfei Shi,Jingtong Zhao,Kongrong Long,Mohan Gao,Fangman Chen,Xuenian Chen,Yue Zhang,Baoding Huang,Dan Shao,Chao Yang,Liang Wang,Ming Zhang,Kam W. Leong,Li Chen,Kan He
出处
期刊:Biomaterials
[Elsevier]
日期:2023-11-04
卷期号:303: 122366-122366
被引量:9
标识
DOI:10.1016/j.biomaterials.2023.122366
摘要
Osteoarthritis (OA) is a common and complex inflammatory disorder that is frequently compounded by cartilage degradation, synovial inflammation, and osteophyte formation. Damaged chondrocytes release multiple danger mediators that exacerbate synovial inflammation and accelerate the progression to OA. Conventional treatments targeting only a single mediator of OA have failed to achieve a strong therapeutic effect. Addressing the crucial role of multiple danger mediators in OA progression, we prepared polyethylenimine (PEI)-functionalized diselenide-bridged mesoporous silica nanoparticles (MSN-PEI) with cell-free DNA (cfDNA)-binding and anti-oxidative properties. In models of surgery-induced and collagenase-induced arthritis, we showed that these cationic nanoparticles attenuated cartilage degradation and provided strong chondroprotection against joint damage. Mechanistically, multiple target blockades alleviated oxidative stress and dampened cfDNA-induced inflammation by suppressing the M1 polarization of macrophages. This study suggests a beneficial direction for targeting multiple danger mediators in the treatment of intractable arthritis.
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