化学
胺化
芳基
胺气处理
磷化氢
催化作用
亲核细胞
基础(拓扑)
卤化物
同种类的
组合化学
配体(生物化学)
有机化学
均相催化
药物化学
数学分析
生物化学
烷基
物理
数学
受体
热力学
作者
Roberto Silva Villatoro,Joshua R. Belfield,Hadi D. Arman,Lucas W. Hernandez,Eric M. Simmons,Zachary J. Garlets,Steven R. Wisniewski,John R. Coombs,Doug E. Frantz
出处
期刊:Organometallics
[American Chemical Society]
日期:2023-11-01
卷期号:42 (21): 3164-3172
被引量:5
标识
DOI:10.1021/acs.organomet.3c00419
摘要
A general method for the Ni-catalyzed Buchwald–Hartwig amination of (hetero)aryl chlorides using both anilines and aliphatic amines under homogeneous conditions has been developed. Key to the success of this method is the implementation of a dual-base strategy that utilizes an amine base combined with a soluble halide scavenger that allows for the use of a single air-stable, commercially available Ni(II)-precatalyst and phosphine ligand [(R,S)-Josiphos] combination to promote aminations across a broad scope of (hetero)aryl chlorides and pharmaceutically relevant amine nucleophiles at catalyst loadings as low as 1.0 mol %.
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