Prader–Willi syndrome: an update

Sleep disorders in Prader-Willi syndrome (PWS) range from respiratory to neurological disorders of sleep. We now recognize the role of excessive daytime sleepiness (present in the infant period and throughout life), and a modified narcolepsy phenotype with or without cataplexy. Disordered sleep in PWS may present with symptoms pervasive to daily function, including inattention at school, irritability, and behavioral outbursts. This review highlights the spectrum of sleep disordered breathing and neurological disorders of sleep in individuals with PWS as well as the current knowledge of management.This article covers the literature characterizing sleep disorders in PWS, including treatment strategies.The review highlights the importance of considering disorders of sleep in PWS and the current treatment options.