化学
药品
血浆蛋白结合
表面蛋白
人血清白蛋白
血清白蛋白
白蛋白
生物物理学
牛血清白蛋白
药理学
立体化学
生物化学
医学
生物
病毒学
作者
Vibeizonuo Rupreo,Rengka Tissopi,Kakali Baruah,Atanu Singha Roy,Jhimli Bhattacharyya
标识
DOI:10.1021/acs.molpharmaceut.4c00651
摘要
Lobeline (LOB), a naturally occurring alkaloid, has a broad spectrum of pharmacological activities and therapeutic potential, including applications in central nervous system disorders, drug misuse, multidrug resistance, smoking cessation, depression, and epilepsy. LOB represents a promising compound for developing treatments in various medical fields. However, despite extensive pharmacological profiling, the biophysical interaction between the LOB and proteins remains largely unexplored. In the current article, a range of complementary photophysical and cheminformatics methodologies were applied to study the interaction mechanism between LOB and the carrier protein HSA. Steady-state fluorescence and fluorescence lifetime experiments confirmed the static-quenching mechanisms in the HSA-LOB system. "
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