Establishment of reference intervals of haematology and biochemistry analytes in ICR mice of different ages

平均红细胞体积 平均红细胞血红蛋白浓度 血液学 肌酐 生理学 平均红细胞血红蛋白 内科学 碱性磷酸酶 生物 白细胞 白蛋白 参考值 年龄组 方差分析 血红蛋白 内分泌学 医学 生物化学 人口学 社会学
作者
Suresh Patel,Satish Patel,Ashvin Kotadiya,Samir Patel,Bhavesh Shrimali,Tushar M. Patel,Harshida Trivedi,Vishal Patel,Jogeswar Mahapatra,Mukul R. Jain
出处
期刊:Laboratory Animals [SAGE Publishing]
被引量:2
标识
DOI:10.1177/00236772241260909
摘要

Outbred stocks of mice are widely used in pre-clinical research as these animals possess a diversified genetic background when compared with inbred strains of mice. It is crucial to assess particular alterations in the physiological and functional profiles of laboratory animals using haematological and biochemical indicators. These values can also differ between laboratories because they are influenced by many different factors. We aimed to provide normal values and reference intervals for selected haematology and biochemistry analytes of 570 ICR mice at three different ages: 6–8 weeks, 10–14 weeks and 6–9 months. Reference values were calculated by non-parametric methods. For comparisons between sexes, the independent-sample t-test and Mann–Whitney test were employed, and analysis of variance was used for age differences. The findings of the study revealed age-related declines in haemoglobin concentration, haematocrit, mean corpuscular volume and mean corpuscular haemoglobin concentrations. Mice aged 6–9 months had statistically higher platelet counts in their blood than mice of other ages. The white blood cell count had a significant age effect and progressively decreased with age. As mice get older, the percentage of neutrophils, monocytes and basophils increases, but the percentage of lymphocytes decreases. For the biochemical values, age-related significant differences in glucose, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and albumin concentrations were found. It was also found that creatinine concentrations were comparable across all age ranges. The values presented in the present work can be used as a reference to interpret clinical pathology data for other studies and to evaluate health status.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Nomiy完成签到,获得积分10
刚刚
maomao完成签到 ,获得积分10
刚刚
可靠觅珍给Wjc的求助进行了留言
1秒前
小狸完成签到,获得积分10
1秒前
spinor完成签到,获得积分10
1秒前
A梦完成签到,获得积分20
1秒前
2秒前
2秒前
liourg发布了新的文献求助10
2秒前
2秒前
发酱完成签到,获得积分10
2秒前
CMJ发布了新的文献求助10
2秒前
WWshu发布了新的文献求助30
2秒前
英俊的铭应助abcdefg采纳,获得10
3秒前
zhengzhao发布了新的文献求助10
3秒前
4秒前
东北雨姐发布了新的文献求助10
4秒前
lyw发布了新的文献求助10
4秒前
搜集达人应助涵泽采纳,获得10
5秒前
limeOrca完成签到,获得积分20
5秒前
impala完成签到,获得积分10
6秒前
6秒前
6秒前
伶俐念珍完成签到 ,获得积分10
6秒前
科研通AI2S应助xiang采纳,获得10
7秒前
搞怪梦寒发布了新的文献求助10
7秒前
好困发布了新的文献求助10
7秒前
8秒前
科研通AI2S应助一一一采纳,获得10
8秒前
Tianju发布了新的文献求助10
8秒前
许晓蝶完成签到,获得积分10
8秒前
9秒前
10秒前
10秒前
岑广山发布了新的文献求助10
10秒前
丘比特应助CMJ采纳,获得10
11秒前
11秒前
RUINNNO完成签到,获得积分10
11秒前
fffffffq发布了新的文献求助10
11秒前
大美女完成签到,获得积分10
12秒前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
Christian Women in Chinese Society: The Anglican Story 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3961589
求助须知:如何正确求助?哪些是违规求助? 3507917
关于积分的说明 11138698
捐赠科研通 3240341
什么是DOI,文献DOI怎么找? 1790929
邀请新用户注册赠送积分活动 872649
科研通“疑难数据库(出版商)”最低求助积分说明 803306