Establishment of reference intervals of haematology and biochemistry analytes in ICR mice of different ages

平均红细胞体积 平均红细胞血红蛋白浓度 血液学 肌酐 生理学 平均红细胞血红蛋白 内科学 碱性磷酸酶 生物 白细胞 白蛋白 参考值 年龄组 方差分析 血红蛋白 内分泌学 医学 生物化学 人口学 社会学
作者
Suresh Patel,Satish Patel,Ashvin Kotadiya,Samir Patel,Bhavesh Shrimali,Tushar M. Patel,Harshida Trivedi,Vishal Patel,Jogeswar Mahapatra,Mukul R. Jain
出处
期刊:Laboratory Animals [SAGE Publishing]
被引量:2
标识
DOI:10.1177/00236772241260909
摘要

Outbred stocks of mice are widely used in pre-clinical research as these animals possess a diversified genetic background when compared with inbred strains of mice. It is crucial to assess particular alterations in the physiological and functional profiles of laboratory animals using haematological and biochemical indicators. These values can also differ between laboratories because they are influenced by many different factors. We aimed to provide normal values and reference intervals for selected haematology and biochemistry analytes of 570 ICR mice at three different ages: 6–8 weeks, 10–14 weeks and 6–9 months. Reference values were calculated by non-parametric methods. For comparisons between sexes, the independent-sample t-test and Mann–Whitney test were employed, and analysis of variance was used for age differences. The findings of the study revealed age-related declines in haemoglobin concentration, haematocrit, mean corpuscular volume and mean corpuscular haemoglobin concentrations. Mice aged 6–9 months had statistically higher platelet counts in their blood than mice of other ages. The white blood cell count had a significant age effect and progressively decreased with age. As mice get older, the percentage of neutrophils, monocytes and basophils increases, but the percentage of lymphocytes decreases. For the biochemical values, age-related significant differences in glucose, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and albumin concentrations were found. It was also found that creatinine concentrations were comparable across all age ranges. The values presented in the present work can be used as a reference to interpret clinical pathology data for other studies and to evaluate health status.
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