Ag(I)-Mediated Site-Selective C(sp2)-H Chalcogenation of Tryptophan-Peptides with Dichalcogenides at Room Temperature

This report presents a silver-mediated site-selective chalcogenation of tryptophan-containing peptides with various dichalcogenides (disulfides/diselenides) at room temperature in good to excellent yields. The significant features include broad substrate scope, functional group diversity, late-stage modification of drug molecules (Dopamine and Levodopa), and various valuable postsynthetic transformations under mild conditions.