化学
一氧化氮
青光眼
体内
药理学
刺激
体外
组合化学
生物化学
有机化学
眼科
医学
生物
免疫学
生物技术
作者
Cunrui Li,Mingchao Zhu,Songqi Liu,Jiaming Zhang,Hui Ye,Shouxin Zhang,Duorui Ji,Haoyang Tang,Yihua Zhang,Jianbing Wu,Zhangjian Huang
标识
DOI:10.1021/acs.jmedchem.4c01199
摘要
Based on the synergistic therapeutic effect of nitric oxide (NO) and Rho-associated protein kinase (ROCK) inhibitors on glaucoma, a series of NO-donating Netarsudil derivatives were designed, synthesized, and their activities in vitro and in vivo were evaluated. Among them, (
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