Ph3P═O-Catalyzed Reductive Deoxygenation of Alcohols

Reductive deoxygenation of alcohols is particularly challenging because of the high bond dissociation energy of the C–OH bond and the poor leaving ability of the hydroxyl group. Herein we describe a Ph3P═O-catalyzed reductive deoxygenation of benzyl alcohols with PhSiH3 under an air atmosphere within 30 min of reaction time. The use of catalytic loading of Ph3P═O enhances the practicality of this protocol.