神经科学
临床神经科学
感知
心理学
痛觉
系统神经科学
医学
认知科学
神经学
麻醉
中枢神经系统
少突胶质细胞
髓鞘
作者
Angélica Rivera-Villaseñor,Frida Higinio-Rodríguez,Mónica López‐Hidalgo
出处
期刊:Advances in neurobiology
日期:2024-01-01
卷期号:: 193-212
标识
DOI:10.1007/978-3-031-64839-7_8
摘要
Astrocytes play an active role in the function of the brain integrating neuronal activity and regulating back neuronal dynamic. They have recently emerged as active contributors of brain's emergent properties such as perceptions. Here, we analyzed the role of astrocytes in pain perception from the lens of systems neuroscience, and we do this by analyzing how astrocytes encode nociceptive information within brain processing areas and how they are key regulators of the internal state that determines pain perception. Specifically, we discuss the dynamic interactions between astrocytes and neuromodulators, such as noradrenaline, highlighting their role in shaping the level of activation of the neuronal ensemble, thereby influencing the experience of pain. Also, we will discuss the possible implications of an "Astro-NeuroMatrix" in the integration of pain across sensory, affective, and cognitive dimensions of pain perception.
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