Hydroxychloroquine Platinum(IV) Conjugate Displaying Potent Antimetastatic Activities by Suppressing Autophagy to Improve the Tumor Microenvironment

Protective autophagy is a promising target for antitumor drug exploration. A hydroxychloroquine (HCQ) platinum(IV) complex with autophagy suppressing potency was developed, which displayed potent antitumor activities with a TGI rate of 44.2% against 4T1 tumors