颠倒
缺血
药理学
化学
医学
内科学
材料科学
复合材料
作者
Yinhao Zhang,Jiaorong Qu,Rong‐Hua Luo,Kexin Jia,Guifang Fan,Fanghong Li,Ruiyu Wu,Jianan Li,Xiaojiaoyang Li
标识
DOI:10.1016/j.phymed.2024.155923
摘要
Hepatic ischemia-reperfusion injury (HIRI) is commonly observed in cases of extensive hepatic resection and involves complex mechanisms. Cell senescence has been recognized as a factor in liver injury including HIRI, where it presents as a pro-inflammatory phenotype called senescence-associated secretory phenotype (SASP). Radix Rehmanniae Praeparata (RRP) is a commonly utilized traditional Chinese medicine known for its hepatoprotective, anti-aging and antioxidant qualities. Despite its recognized benefits, the specific mechanisms by which RRP may impede the progression of HIRI through the regulation of cell senescence and the identification of the most potent anti-aging extracts from RRP remain unclear.
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