纳米笼
自愈水凝胶
离解(化学)
聚乙二醇
化学
化学工程
生物物理学
高分子化学
有机化学
催化作用
工程类
生物
作者
Erika Nasu,Norifumi Kawakami,Shuhei Takamura,Atsushi Hotta,Ryoichi Arai,Kenji Miyamoto
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2024-03-06
卷期号:25 (4): 2358-2366
被引量:1
标识
DOI:10.1021/acs.biomac.3c01285
摘要
Oligomeric protein nanocages often disassemble into their subunits and reassemble by external stimuli. Thus, using these nanocages as cross-linkers for hydrogel network structures is a promising approach to allow hydrogels to undergo stimuli-responsive gel–sol transitions or self-healing. Here, we report hydrogels that show a reversible gel–sol transition resulting from the heat-induced dissociation and reassociation of protein nanocages. The hydrogel contained the 60-mer artificial protein nanocage, TIP60, as a supramolecular cross-linker for polyethylene glycol network structures. The hydrogel showed a gel-to-sol transition upon heating at a temperature above the melting point of TIP60 and immediately returned to a gel state upon cooling to room temperature. During the heating and cooling treatment of the hydrogel, small-angle X-ray scattering analysis suggested the dissociation and reassociation of TIP60. Furthermore, we demonstrated redox-responsive cargo release from TIP60 in the hydrogel. These results showed the potential of TIP60 as a component of multi-stimuli-responsive hydrogels.
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