自愈水凝胶
生物相容性
韧性
再生(生物学)
纳米技术
材料科学
细胞外基质
组织工程
石墨烯
纳米结构
脆性
生物医学工程
复合材料
高分子化学
生物
化学
细胞生物学
医学
生物化学
冶金
作者
Yonghyun Gwon,Sangbae Park,Woochan Kim,Sunho Park,Harshita Sharma,Hoon Eui Jeong,Hyunjoon Kong,Jangho Kim
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-02-07
卷期号:24 (7): 2188-2195
被引量:1
标识
DOI:10.1021/acs.nanolett.3c04188
摘要
Over the past few decades, hydrogels have attracted considerable attention as promising biomedical materials. However, conventional hydrogels require improved mechanical properties, such as brittleness, which significantly limits their widespread use. Recently, hydrogels with remarkably improved toughness have been developed; however, their low biocompatibility must be addressed. In this study, we developed a tough graphene hybrid hydrogel with nanostructures. The resultant hydrogel exhibited remarkable mechanical properties while representing an aligned nanostructure that resembled the extracellular matrix of soft tissue. Owing to the synergistic effect of the topographical properties, and the enhanced biochemical properties, the graphene hybrid hydrogel had excellent stretchability, resilience, toughness, and biocompatibility. Furthermore, the hydrogel displayed outstanding tissue regeneration capabilities (e.g., skin and tendons). Overall, the proposed graphene hybrid tough hydrogel may provide significant insights into the application of tough hydrogels in tissue regeneration.
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