线粒体
荧光团
光热治疗
化学
光动力疗法
细胞器
生物物理学
荧光
癌细胞
癌症
癌症研究
纳米技术
生物化学
材料科学
生物
物理
遗传学
有机化学
量子力学
作者
Honghai Zhao,Kai Chen,Mengwei Liu,Sheng Wang,Lei Li,Meixing Li,Pengfei Sun,Hui Zhou,Quli Fan,Qingming Shen
标识
DOI:10.1021/acs.jmedchem.3c01677
摘要
Subcellular organelle mitochondria are becoming a key player and a driver of cancer. Mitochondrial targeting phototheranostics has attracted increasing attention for precise cancer therapy. However, those phototheranostic systems still face great challenges, including complex and multiple components, light scattering, and insufficient therapeutic efficacy. Herein, a molecular fluorophore IR-TPP-1100 was tactfully designed by molecular engineering for mitochondria-targeted fluorescence imaging-guided phototherapy in the second near-infrared window (NIR-II). IR-TPP-1100 not only exhibited prominent photophysical properties and high photothermal conversion efficiency but also achieved excellent mitochondria-targeting ability. The mitochondria-targeting IR-TPP-1100 enabled NIR-II fluorescence and photoacoustic dual-modality imaging of mitochondria at the organism level. Moreover, it integrated photothermal and photodynamic therapy, obtaining remarkable tumor therapeutic efficacy by inducing mitochondrial apoptosis. These results indicate that IR-TPP-1100 has great potential for precise cancer therapy and provides a promising strategy for developing mitochondria-targeting NIR-II phototheranostic agents.
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