[Research progress on the role of glucose in regulating immune homeostasis].

Glucose is the central nutrient for energy metabolism and life support in the human body. As the main energy substance of the body, glucose is essential for the normal function of immune cells and their proliferation; when glucose homeostasis is disrupted in the body, it may lead to impaired immune system function and pathological conditions. Exploring the relationship between glucose metabolism and immune regulation can help establish the gene regulatory network and figure out potential pathogenic mechanisms under physiological and pathological conditions. This article reviews the current scientific research progress on glucose metabolism and immunity, mainly focusing on the physiological regulatory functions of glucose in maintaining the homeostasis of innate and acquired immunity; and summarizes the research progress on the effects and mechanisms of glucose on tumor immunity and its related therapies under pathological conditions, taking tumors as an example.葡萄糖是人体能量代谢和维持生命所必需的营养物质之一。作为机体主要的能源物质，葡萄糖对免疫细胞的正常功能及其增殖至关重要；当体内葡萄糖平衡遭到破坏时，可能导致免疫系统功能受损和病理状况产生。分析葡萄糖代谢与机体免疫调控的关系，有助于建立生理和病理状况下糖与免疫之间的分子调控网络和潜在的致病机制。本文阐述了目前葡萄糖代谢与机体免疫新近的研究进展，重点围绕葡萄糖对维持机体先天免疫和适应性免疫稳态的生理调节功能；并以肿瘤为例，研究了在病理状况下葡萄糖对于肿瘤免疫及其相关疗法影响和机制的新进展。.