Association between triglyceride glucose index and total bone mineral density: a cross-sectional study from NHANES 2011–2018

甘油三酯 腰围 横断面研究 骨矿物 医学 体质指数 代谢综合征 胰岛素抵抗 内分泌学 内科学 数学 肥胖 胆固醇 骨质疏松症 病理
作者
Ningsheng Tian,Daiwen Chen,Huawei Han,Jie Jin,Zhiwei Li
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:14 (1) 被引量:9
标识
DOI:10.1038/s41598-024-54192-9
摘要

Abstract The Homeostatic Model Assessment for Triglyceride Glucose Index (TyG) and its related indices, including triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist-to-height ratio (TyG-WHtR) and triglyceride glucose-body mass index (TyG-BMI), has emerged as a practical tool for assessing insulin resistance in metabolic disorders. However, limited studies have explored the connection between TyG, TyG-related indices and osteoporosis. This population-based study, utilizing data from the National Health and Nutrition Examination Survey 2011–2018, involved 5456 participants. Through weighted multivariate linear regression and smoothed curve fitting, a significant positive correlation was found between TyG, TyG-related indices and total bone mineral density (BMD) after adjusting for covariates [β = 0.0124, 95% CI (0.0006, 0.0242), P = 0.0390; β = 0.0004, 95% CI (0.0003, 0.0004), P < 0.0001; β = 0.0116, 95% CI (0.0076, 0.0156), P < 0.0001; β = 0.0001, 95% CI (0.0001, 0.0001), P < 0.0001]. In subgroup analysis, race stratification significantly affected the relationship between TyG and total BMD. Additionally, gender and race were both significant for TyG-related indices. Non-linear relationships and threshold effects with inflection points at 9.106, 193.9265, 4.065, and 667.5304 (TyG, TyG-BMI, TyG-WHtR, TyG-WC) were identified. Saturation phenomena were observed between TyG-BMI, TyG-WC and total BMD with saturation thresholds at 314.177 and 1022.0428. These findings contributed to understanding the association between TyG, TyG-related indices and total BMD, offering insights for osteoporosis prevention and treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
Vicki完成签到,获得积分10
刚刚
wxs完成签到,获得积分10
1秒前
leezhen完成签到,获得积分10
1秒前
上官若男应助Michael采纳,获得10
1秒前
喵喵发布了新的文献求助10
1秒前
Blue完成签到,获得积分10
1秒前
bpg28发布了新的文献求助10
2秒前
eeo完成签到,获得积分10
2秒前
Orange应助沟通亿心采纳,获得10
2秒前
阿猫发布了新的文献求助10
3秒前
3秒前
3秒前
wxs发布了新的文献求助10
4秒前
4秒前
CodeCraft应助铁柱采纳,获得10
4秒前
博士后完成签到,获得积分10
4秒前
正能量发布了新的文献求助10
5秒前
5秒前
7秒前
7秒前
小逗逗n号发布了新的文献求助10
7秒前
8秒前
Violet发布了新的文献求助10
8秒前
8秒前
杨馨蕊完成签到 ,获得积分10
9秒前
南山有只大肥羊完成签到,获得积分10
9秒前
Manana完成签到 ,获得积分10
9秒前
CipherSage应助黎明之前采纳,获得10
9秒前
10秒前
海豚完成签到,获得积分10
10秒前
小马甲应助药宫采纳,获得10
10秒前
燕燕发布了新的文献求助10
10秒前
10秒前
10秒前
Active发布了新的文献求助10
10秒前
H哈发布了新的文献求助10
11秒前
11秒前
11秒前
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970287
求助须知:如何正确求助?哪些是违规求助? 3515034
关于积分的说明 11176923
捐赠科研通 3250301
什么是DOI,文献DOI怎么找? 1795244
邀请新用户注册赠送积分活动 875732
科研通“疑难数据库(出版商)”最低求助积分说明 805039