类风湿性关节炎
炎症
骨愈合
自愈水凝胶
化学
关节炎
免疫系统
医学
内生
骨侵蚀
药理学
癌症研究
免疫学
外科
生物化学
有机化学
作者
Wenbo Geng,Jie Zhao,Bailong Tao,Yukui Zhang,Qiaojian Duan,Pengfei Gao,Tingting He,Shaopeng Liu,Qian Feng,Peng Zhao,Kaiyong Cai
标识
DOI:10.1016/j.bioactmat.2024.03.002
摘要
The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop a dual-gas-mediated injectable hydrogel for modulating the immune microenvironment of RA and simultaneously releasing therapeutic drugs. The hydrogel (DNRS gel) could be broken down on-demand by consuming excessive nitric oxide (NO) and releasing therapeutic hydrogen sulfide (H2S), resulting in endogenous gas restoration, inflammation alleviation, and macrophage polarization to M2 type. Additionally, the hydrogel could suppress osteoclastogenesis and enhance osteogenesis. Furthermore, the intra-articularly injected hydrogel with methotrexate (MTX/DNRS gel) significantly alleviated inflammation and clinical symptoms and promoted the repair of bone erosion in the collagen-induced arthritis rat model. As a result, in vivo results demonstrated that MTX/DNRS gel restored the microenvironment and improved the therapeutic effect of MTX. This study provides a novel understanding of developing versatile smart delivery platforms for RA treatment.
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