分离(微生物学)
重症监护室
预测值
医学
内科学
接收机工作特性
克
重症监护医学
生物
细菌
微生物学
遗传学
作者
Alicia Carranza,Natalia Chueca,De Salazar A,Arturo Huerta de la Peña,E Yuste,Féderico García,Manuel Colmenero
标识
DOI:10.1016/j.diagmicrobio.2024.116250
摘要
In ICU settings, screening patients upon admission for potential multiresistant bacteria (BMR) carriers is crucial. Traditionally, clinical decisions relied on delayed culture results, but a rapid PCR molecular test called RealCycler-Rezero-U/G (Progenie-molecular©), emerged as an alternative. This study aimed to validate its effectiveness in detecting gram-negative BMR in rectal swabs at ICU admission. Over 24 months, an observational study was conducted on 1,234 admitted patients, with 217 meeting isolation criteria and undergoing both PCR and culture tests. Results showed a 17.5% positive rate for screening. The PCR test exhibited impressive accuracy at 98.6% and a strong negative predictive value of 99.4%. The area under the ROC curve (AUC) was 0.98, indicating high reliability. Notably, PCR results were available 44.5 hours earlier than culture. In conclusion, PCR-based molecular testing for gram-negative BMR offers excellent diagnostic performance and a valuable negative predictive value, making it a suitable screening tool for ICU admissions.
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