Correlation of D-dimer Levels with Fasting Blood Glucose Levels in Patients with Type 2 Diabetes Mellitus

Chronic hyperglycemia in patients with Type 2 Diabetes Mellitus (T2DM) can cause damage to various organs, resulting in both microvascular and macrovascular complications that lead to an increased risk of cardiovascular disease. One of the markers that can detect vascular disorders is D-dimer levels. Fasting blood glucose (FBG) analysis in T2DM patients associated with D-dimer levels is important to know to be used as an indicator in connection with diabetes complications, especially vascular complications. This study aims to determine the correlation between D-dimer levels and FGB. The study was conducted in three hospitals in North Sulawesi province. The study population was T2DM patients (as evidenced by fasting blood glucose >126mg/dL) who examined themselves in the period January-June 2023. Samples were obtained using the total sampling method, where all populations that met the inclusion and exclusion criteria were used as participants. Ninety-four patients with T2DM (62 women and 32 men) were eligible to be participants in this study. Blood pressure, GDP and D-dimer were examined. Based on the results of the blood pressure examination, 40 participants suffered from hypertension and 54 participants did not. The average values of blood glucose, HbA1c and D-dimer levels in hypertensive and non-hypertensive participants are not much different. The results of the analysis using Spearman's rho showed that there was a moderate correlation between D-dimer levels and GDP (p=0.03, r=0.302). In conclusion, although there is a moderate correlation between D-dimer levels and fasting blood glucose levels, D-dimer is not recommended to be used as an indicator of complications in T2DM.