Relationships of Hematocrit With Chronic Covert and Acute Symptomatic Lacunar Ischemic Lesions

医学 红细胞压积 腔隙性中风 冲程(发动机) 内科学 半影 心脏病学 人口 队列 隐蔽的 缺血性中风 缺血 哲学 工程类 环境卫生 机械工程 语言学
作者
David Roh,Ricardo Murguia-Fuentes,Kursat Gurel,Farid Khasiyev,Salwa Rahman,Pedro Bueno,Khrystyna Kozii,Antonio Spagnolo‐Allende,Azzurra Cottarelli,Marialaura Simonetto,Robin Ji,Jia Guo,Vadim Spektor,Eldad A. Hod,Devin Burke,Elisa Konofagou,Tatjana Rundek,Clinton B. Wright,Randolph S. Marshall,Mitchell S.V. Elkind,José Gutierrez
出处
期刊:Neurology [Ovid Technologies (Wolters Kluwer)]
卷期号:102 (2) 被引量:1
标识
DOI:10.1212/wnl.0000000000207961
摘要

Background and Objectives Red blood cell (RBC) concentrations are known to associate with ischemic stroke. It is unclear whether RBC concentrations associate specifically with small vessel disease lacunar infarcts. We investigated the hypothesis that RBC concentrations associate with both chronic covert and acute symptomatic brain MRI lacunar infarcts. Methods A cross-sectional observational analysis was performed across 2 cohorts with available hematocrit (as the assessment of RBC concentration exposure) and MRI outcome data. The primary setting was a population-based cohort of stroke-free, older adult (>50 years) participants from the Northern Manhattan Study (NOMAS) enrolled between 2003 and 2009. A second replication sample consisted of patients admitted with acute stroke and enrolled into the Columbia Stroke Registry (CSR) between 2005 and 2020. Associations of hematocrit with (1) chronic, covert lacunar infarcts and (2) symptomatic (i.e., acute) lacunar strokes were separately assessed from the NOMAS and CSR cohorts, respectively, using general additive models after adjusting for relevant covariates. Results Of 1,218 NOMAS participants analyzed, 6% had chronic, covert lacunar infarcts. The association between hematocrit and these covert lacunar infarcts was U-shaped (χ 2 = 9.21 for nonlinear associations; p = 0.03), with people with hematocrit extremes being more likely to have covert lacunar infarcts. Of the 1,489 CSR patients analyzed, 23% had acute lacunar strokes. In this sample, only the relationships of increased hematocrit concentrations and lacunar strokes were replicated (adjusted coefficient β = 0.020; SE = 0.009; p = 0.03). Discussion We identified relationships of hematocrit with MRI lacunar infarcts in both stroke-free and ischemic stroke cohorts, respectively. The relationship between increased hematocrit concentrations with lacunar infarcts was replicated in both cohorts. Further studies are required to clarify the mechanisms behind the relationships of hematocrit with ischemic cerebral small vessel disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
南瓜完成签到 ,获得积分10
5秒前
jhxie完成签到 ,获得积分10
8秒前
18062677029完成签到 ,获得积分10
17秒前
桃儿完成签到 ,获得积分10
18秒前
22秒前
angle完成签到,获得积分10
23秒前
24秒前
满意代亦完成签到 ,获得积分10
26秒前
水文小白完成签到,获得积分10
27秒前
宝宝发布了新的文献求助10
27秒前
欢喜板凳完成签到 ,获得积分10
28秒前
乐观的海发布了新的文献求助10
31秒前
Ade完成签到,获得积分10
32秒前
我不会乱起名字的完成签到,获得积分10
38秒前
kehe!完成签到 ,获得积分0
40秒前
丹妮完成签到 ,获得积分10
40秒前
宝宝完成签到,获得积分10
43秒前
共享精神应助宝宝采纳,获得10
45秒前
46秒前
savior完成签到 ,获得积分10
46秒前
zhugao完成签到,获得积分10
48秒前
九月完成签到 ,获得积分10
49秒前
帆320完成签到,获得积分10
54秒前
跳跃完成签到,获得积分10
1分钟前
Accept完成签到,获得积分10
1分钟前
Sharon完成签到 ,获得积分10
1分钟前
一张不够花完成签到 ,获得积分10
1分钟前
weihe完成签到 ,获得积分10
1分钟前
zzll0301完成签到,获得积分10
1分钟前
生言生语完成签到,获得积分10
1分钟前
zombleq完成签到 ,获得积分10
1分钟前
幼荷完成签到 ,获得积分10
1分钟前
shuangfeng1853完成签到 ,获得积分10
1分钟前
开心的刚完成签到,获得积分10
1分钟前
重要的夏天完成签到,获得积分10
1分钟前
火星上白羊完成签到,获得积分10
1分钟前
小布瓜完成签到 ,获得积分10
1分钟前
1分钟前
锦鲤完成签到 ,获得积分10
1分钟前
心心发布了新的文献求助10
1分钟前
高分求助中
Lire en communiste 1000
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 800
Becoming: An Introduction to Jung's Concept of Individuation 600
Communist propaganda: a fact book, 1957-1958 500
Briefe aus Shanghai 1946‒1952 (Dokumente eines Kulturschocks) 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3167235
求助须知:如何正确求助?哪些是违规求助? 2818724
关于积分的说明 7922021
捐赠科研通 2478475
什么是DOI,文献DOI怎么找? 1320350
科研通“疑难数据库(出版商)”最低求助积分说明 632776
版权声明 602443