医学
前瞻性队列研究
内科学
炎症性肠病
膳食纤维
队列研究
炎症性肠病
队列
膳食纤维
胃肠病学
疾病
食品科学
化学
作者
Minzi Deng,Lintao Dan,Shuyu Ye,Xuejie Chen,Tian Fu,Xiaoyan Wang,Jie Chen
摘要
Summary Background Limited prospective studies that have examined the association of dietary fibre with IBD have provided inconsistent evidence. Aim To examine any associations between dietary fibre intake and subsequent incidence of IBD, Crohn's disease (CD) and ulcerative colitis (UC) Methods We conducted a prospective cohort study of 470,669 participants from the UK Biobank and estimated dietary fibre intake from a valid food frequency questionnaire at baseline. Incident IBD was ascertained from primary care data and inpatient data. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between dietary fibre intake and the risk of IBD, CD and UC. Results During an average follow‐up of 12.1 years, we ascertained 1473 incident IBD cases, including 543 cases of CD and 939 cases of UC. Comparing the lowest quintiles, an inverse association was observed between dietary fibre intake and risk of IBD (HR 0.74, 95% CI 0.58–0.93, p = 0.011) and CD (HR 0.48, 95% CI 0.32–0.72, p < 0.001), but not UC (HR 0.92, 95% CI 0.69–1.24, p = 0.595). For specified sources, dietary fibre intake from fruit and bread decreased the risk of CD, while dietary fibre intake from cereal decreased the risk of UC. Conclusions Higher consumption of dietary fibre was associated with a lower risk of IBD and CD, but not UC. Our findings support current recommendations to increase the intake of dietary fibre.
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