Prediction of programmed death-1 expression status in non–small cell lung cancer based on intratumoural and peritumoral computed tomography (CT) radiomics nomogram

医学 列线图 无线电技术 置信区间 肺癌 队列 肿瘤科 核医学 回顾性队列研究 放射科 内科学
作者
Q. Tian,J.Y. Jia,Chao Qin,Hao Zhou,Shi-Yu Zhou,Qin Ye,Yuanyuan Wu,Jian Shi,Shao Feng Duan,Fred Feng
出处
期刊:Clinical Radiology [Elsevier BV]
卷期号:79 (9): e1089-e1100
标识
DOI:10.1016/j.crad.2024.05.008
摘要

AIM This study aimed to predict the expression of programmed death-1 (PD-1) in non-small cell lung cancer (NSCLC) using intratumoural and peritumoural computed tomography (CT) radiomics nomogram. MATERIALS AND METHODS Two hundred patients pathologically diagnosed with NSCLC from two hospitals were retrospectively analysed. Of these, 159 NSCLC patients from our hospital were randomly divided into a training cohort (n=96) and an internal validation cohort (n=63) at a ratio of 6:4, while 41 NSCLC patients from another medical institution served as the external validation cohort. The radiomic features of the gross tumour volume (GTV) and peritumoral volume (PTV) were extracted from the CT images. Optimal radiomics features were selected using least absolute shrinkage and selection operator regression analysis. Finally, a CT radiomics nomogram of clinically independent predictors combined with the best rad-score was constructed. RESULTS Compared with the 'GTV' and 'PTV' radiomics models, the combined 'GTV + PTV' radiomics model showed better predictive performance, and its AUC values in the training, internal validation, and external validation cohorts were 0.90 (95% confidence interval [CI]: 0.83-0.97), 0.85 (95% CI: 0.74-0.96) and 0.78 (95% CI: 0.63-0.92). The nomogram constructed by the rad-score of the 'GTV + PTV' radiomics model combined with clinical independent predictors (prealbumin and monocyte) had the best performance, with AUC values in each cohort being 0.92 (95% CI: 0.85-0.98), 0.88 (95% CI: 0.78-0.97), and 0.80 (95% CI: 0.66-0.94), respectively. CONCLUSIONS The intratumoural and peritumoral CT radiomics nomogram may facilitate individualised prediction of PD-1 expression status in patients with NSCLC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
leng完成签到 ,获得积分10
刚刚
刚刚
宿帅帅完成签到,获得积分10
刚刚
tszjw168发布了新的文献求助10
1秒前
1秒前
2秒前
2秒前
cmxx完成签到 ,获得积分10
3秒前
大个应助shuo采纳,获得10
3秒前
4秒前
CAS_lyw发布了新的文献求助10
4秒前
冷静映寒发布了新的文献求助10
4秒前
李健应助大道要熬采纳,获得10
4秒前
5秒前
5秒前
sandy_bear发布了新的文献求助20
5秒前
领导范儿应助小七采纳,获得10
6秒前
可爱的函函应助小马采纳,获得10
6秒前
清爽的亦瑶完成签到 ,获得积分10
6秒前
6秒前
lalala完成签到,获得积分10
7秒前
Jasper应助LDDD采纳,获得10
8秒前
Hello应助xiaoqian采纳,获得10
9秒前
9秒前
谦让的樱发布了新的文献求助10
9秒前
Li完成签到,获得积分10
10秒前
lalala发布了新的文献求助10
10秒前
香蕉觅云应助现代的无春采纳,获得10
11秒前
Pool完成签到 ,获得积分10
11秒前
Sam发布了新的文献求助10
11秒前
SYLH应助cc采纳,获得20
11秒前
LCCCC完成签到,获得积分10
11秒前
英姑应助追寻夜安采纳,获得10
12秒前
乐乐应助不吃萝卜采纳,获得10
12秒前
冷酷莫茗发布了新的文献求助10
12秒前
优雅的涵瑶完成签到,获得积分20
13秒前
田田完成签到 ,获得积分10
13秒前
13秒前
14秒前
MeOH拿桶接完成签到,获得积分10
14秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
徐淮辽南地区新元古代叠层石及生物地层 500
Robot-supported joining of reinforcement textiles with one-sided sewing heads 400
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4023306
求助须知:如何正确求助?哪些是违规求助? 3563350
关于积分的说明 11342113
捐赠科研通 3294890
什么是DOI,文献DOI怎么找? 1814795
邀请新用户注册赠送积分活动 889504
科研通“疑难数据库(出版商)”最低求助积分说明 812964