Enzyme‐Like Photocatalytic Octahedral Rh/Ag 2 MoO 4 Accelerates Diabetic Wound Healing by Photo‐Eradication of Pathogen and Relieving Wound Hypoxia

Abstract The harsh environment of diabetic wounds, including bacterial infection and wound hypoxia, is not conducive to wound healing. Herein, an enzyme‐like photocatalytic octahedral Rh/Ag 2 MoO 4 is developed to manage diabetic‐infected wounds. The introduction of Rh nanoparticles with catalase‐like catalytic activity can enhance the photothermal conversion and photocatalytic performance of Rh/Ag 2 MoO 4 by improving near‐infrared absorbance and promoting the separation of electron‐hole pairs, respectively. Rh/Ag 2 MoO 4 can effectively eliminate pathogens through a combination of photothermal and photocatalytic antibacterial therapy. After bacteria inactivation, Rh/Ag 2 MoO 4 can catalyze hydrogen peroxide to produce oxygen to alleviate the hypoxic environment of diabetic wounds. The in vivo treatment effect demonstrated the excellent therapeutic performance of Rh/Ag 2 MoO 4 on diabetic infected wounds by removing infectious pathogens and relieving oxygen deficiency, confirming the potential application of Rh/Ag 2 MoO 4 in the treatment of diabetic infected wounds.