埃博拉病毒
塞拉利昂
爆发
医学
亚临床感染
疾病
队列
抗体
免疫学
中和抗体
病毒学
免疫系统
内科学
发展经济学
经济
作者
Nell G. Bond,Kayla Shore,Emily J. Engel,Erin Coonan,Foday Alhasan,Michael Gbakie,Fatima K. Kamara,Lansana Kanneh,Mambu Momoh,Ibrahim Mustapha Kanneh,John Demby Sandi,Debra Elliott,Samuel C. Ficenec,Ashley R. Smira,William A. Fischer,David A. Wohl,James E. Robinson,Jeffrey G. Shaffer,Robert F. Garry,Robert J. Samuels,Donald S. Grant,John S. Schieffelin
标识
DOI:10.1093/infdis/jiae155
摘要
Abstract Ebola virus (EBOV) infection results in Ebola virus disease (EVD), an often severe disease with a nonspecific presentation. Since its recognition, periodic outbreaks of EVD continue to occur in sub-Saharan Africa. The 2013–2016 West African EVD outbreak was the largest recorded, resulting in a substantial cohort of EVD survivors with persistent health complaints and variable immune responses. In this study, we characterize humoral immune responses in EVD survivors and their contacts in Eastern Sierra Leone. We found high levels of EBOV IgG in EVD survivors and lower yet substantial antibody levels in household contacts, suggesting subclinical transmission. Neutralizing antibody function was prevalent but variable in EVD survivors, raising questions about the durability of immune responses from natural infection with EBOV. Additionally, we found that certain discrete symptoms—ophthalmologic and auditory—are associated with EBOV IgG seropositivity, while an array of symptoms are associated with the presence of neutralizing antibody.
科研通智能强力驱动
Strongly Powered by AbleSci AI