化学
髓系白血病
表观遗传学
白血病
CREB结合蛋白
髓样
癌症研究
药理学
奶油
内科学
生物化学
转录因子
基因
生物
医学
作者
Tianbang Wu,Jiankang Hu,Xiao‐Fan Zhao,Cheng Zhang,Ruibo Dong,Qingqing Hu,Hongrui Xu,Hui Shen,Xiaohan Zhang,Yan Zhang,Bin Lin,Xishan Wu,Qiuping Xiang,Yong Xu
标识
DOI：10.1021/acs.jmedchem.4c00335
摘要
The epigenetic target CREB (cyclic-AMP responsive element binding protein) binding protein (CBP) and its homologue p300 were promising therapeutic targets for the treatment of acute myeloid leukemia (AML). Herein, we report the design, synthesis, and evaluation of a class of CBP/p300 PROTAC degraders based on our previously reported highly potent and selective CBP/p300 inhibitor
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