病理生理学
肝病
医学
疾病
酒精性肝病
生物
生物信息学
胃肠病学
病理
肝硬化
作者
Fernanda Raya Tonetti,Álvaro Eguileor,Marko Mrdjen,Vai Pathak,Jared Travers,Laura E. Nagy,Cristina Llorente
标识
DOI:10.1097/hep.0000000000000924
摘要
The growing recognition of the role of the gut microbiome’s impact on alcohol-associated diseases, especially in alcohol-associated liver disease, emphasizes the need to understand molecular mechanisms involved in governing organ-organ communication to identify novel avenues to combat alcohol-associated diseases. The gut-liver axis refers to the bidirectional communication and interaction between the gut and the liver. Intestinal microbiota plays a pivotal role in maintaining homeostasis within the gut-liver axis, and this axis plays a significant role in alcohol-associated liver disease. The intricate communication between intestine and liver involves communication between multiple cellular components in each organ that enable them to carry out their physiological functions. In this review, we focus on novel approaches to understanding how chronic alcohol exposure impacts the microbiome and individual cells within the liver and intestine, as well as the impact of ethanol on the molecular machinery required for intraorgan and interorgan communication.
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