类风湿性关节炎
医学
单克隆抗体
抗体
双特异性抗体
免疫学
作者
Aliki I. Venetsanopoulou,Paraskevi V. Voulgari,Alexandros A. Drosos
标识
DOI:10.1080/13543784.2024.2351507
摘要
Rheumatoid arthritis (RA) is an autoimmune disorder with a characteristic chronic inflammation of the synovium that may lead to the destruction of the joints in untreated patients. Interestingly, despite the availability of several effective treatments, many patients do not achieve remission or low disease activity or may experience disease relapse.Following the above unmet needs, bispecific antibodies (BsAbs) have emerged as a new approach to improve the disease's treatment. BsAbs are designed to simultaneously target two different proteins involved in RA pathogenesis, leading to enhanced efficacy and reduced side effects compared to traditional monoclonal antibodies (mAbs).
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