Association between serum magnesium levels and risk of acute kidney injury in patients with traumatic brain injury: A retrospective cohort study from the MIMIC-Ⅳ database

医学 创伤性脑损伤 急性肾损伤 回顾性队列研究 队列研究 队列 内科学 精神科
作者
Jinbang Ma,Xiumin Li,Xinzhi Wang,Zhenxue Xin,Chuangang Wang
出处
期刊:Blood Purification [Karger Publishers]
卷期号:53 (8): 603-612 被引量:2
标识
DOI:10.1159/000539507
摘要

<b><i>Introduction:</i></b> The occurrence of acute kidney injury (AKI) is associated with a higher risk of mortality in patients with traumatic brain injury (TBI). This study aimed to explore the relationship between serum magnesium levels and the risk of AKI in patients with TBI. <b><i>Methods:</i></b> Patients with TBI were identified from the Medical Information Mart Intensive Care IV (MIMIC-IV) 2008–2019. The relationship between serum magnesium levels at admission and magnesium coefficient of variation (CV) during hospitalization and the risk of AKI was analyzed using multivariable logistic regression analysis and expressed as odds ratio (OR) and 95% confidence interval (CI). Subgroup analyses were performed according to Glasgow Coma Scale (GCS) score (&lt;14, ≥14), sepsis (no, yes), and estimated glomerular filtration rate (eGFR; &lt;60, ≥60). <b><i>Results:</i></b> Of the 991 patients included, 140 (14.13%) developed AKI during hospitalization. Patients with magnesium levels ≤1.7 mg/dL (tertile 1) (OR = 1.68, 95% CI: 1.01–2.81) were associated with a higher risk of AKI compared to those with magnesium levels of 1.7–2.0 mg/dL (tertile 2), but no association was found in those with magnesium levels &gt;2.0 mg/dL (tertile 3) (<i>p</i> = 0.479). For magnesium CV, patients with magnesium CV &gt;10% (tertile 3) (OR = 2.26, 95% CI: 1.16–4.41) were linked to an increased risk of AKI compared to those with magnesium CV ≤4% (tertile 1), but there may be a slight association between magnesium CV of 4%–10% (tertile 2) and AKI risk (OR = 1.86, 95% CI: 0.99–3.48; <i>p</i> = 0.053). Subgroup analyses showed that lower magnesium levels (≤1.7 mg/dL) or greater magnesium CV (&gt;10%) were associated with a higher risk of AKI only in patients with a GCS score ≥14, non-sepsis, or eGFR ≥60 mL/min/1.73 m<sup>2</sup> (<i>p</i> &lt; 0.05). <b><i>Conclusion:</i></b> Lower serum magnesium levels at admission or greater magnesium CV during hospitalization were associated with a higher risk of AKI in patients with TBI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
希望天下0贩的0应助kk子采纳,获得10
刚刚
丰富的不惜完成签到,获得积分10
2秒前
票子发布了新的文献求助10
2秒前
华仔应助魏莱采纳,获得10
2秒前
F123发布了新的文献求助10
3秒前
shen发布了新的文献求助10
4秒前
4秒前
苗觉觉完成签到,获得积分10
5秒前
帕金森完成签到,获得积分10
6秒前
活力的妙芙完成签到,获得积分10
6秒前
赘婿应助疯子魔煞采纳,获得10
7秒前
橙橙橙完成签到,获得积分10
7秒前
7秒前
你好CDY完成签到,获得积分10
8秒前
8秒前
8秒前
万能图书馆应助希尔伯特采纳,获得10
8秒前
我是老大应助123采纳,获得10
9秒前
芒果小鹌鹑完成签到,获得积分10
10秒前
上官若男应助F123采纳,获得10
11秒前
Singularity应助邢文瑞采纳,获得10
12秒前
c123发布了新的文献求助10
13秒前
嘉嘉琦发布了新的文献求助10
14秒前
wanci应助QWDSA采纳,获得10
16秒前
16秒前
愉快静曼发布了新的文献求助10
19秒前
乐乐乐乐乐乐应助科学家采纳,获得10
20秒前
99完成签到,获得积分10
20秒前
20秒前
友好傲白完成签到,获得积分10
20秒前
FL完成签到 ,获得积分10
21秒前
量子星尘发布了新的文献求助10
22秒前
清新的绿海完成签到,获得积分10
22秒前
山色青完成签到,获得积分10
23秒前
23秒前
ya完成签到,获得积分10
23秒前
等风来完成签到 ,获得积分10
24秒前
疯子魔煞完成签到,获得积分10
24秒前
执着的招牌完成签到,获得积分10
24秒前
不着四六的岁月完成签到,获得积分10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038446
求助须知:如何正确求助?哪些是违规求助? 3576149
关于积分的说明 11374627
捐赠科研通 3305875
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892680
科研通“疑难数据库(出版商)”最低求助积分说明 815048