PTEN公司
PI3K/AKT/mTOR通路
小RNA
癌变
蛋白激酶B
癌症研究
癌症
转移
生物
信号转导
生物信息学
细胞生物学
遗传学
基因
作者
Sushmaa Chandralekha Selvakumar,K. Auxzilia Preethi,Durairaj Sekar
标识
DOI:10.1016/j.bbcan.2023.188904
摘要
Cancer being the leading cause of mortality has become a great threat worldwide. Current cancer therapeutics lack specificity and have side effects due to a lack of understanding of the molecular mechanisms and signalling pathways involved in carcinogenesis. In recent years, researchers have been focusing on several signalling pathways to pave the way for novel therapeutics. The PTEN/PI3K/AKT pathway is one of the important pathways involved in cell proliferation and apoptosis, leading to tumour growth. In addition, the PTEN/PI3K/AKT axis has several downstream pathways that could lead to tumour malignancy, metastasis and chemoresistance. On the other hand, microRNAs (miRNAs) are important regulators of various genes leading to disease pathogenesis. Hence studies of the role of miRNAs in regulating the PTEN/PI3K/AKT axis could lead to the development of novel therapeutics for cancer. Thus, in this review, we have focused on various miRNAs involved in the carcinogenesis of various cancer via the PTEN/PI3K/AKT axis.
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