Chemoradiotherapy versus triplet chemotherapy as initial therapy for T4b esophageal cancer: survival results from a multicenter randomized Phase 2 trial

医学 临床终点 食管癌 放化疗 随机对照试验 化疗 内科学 多中心试验 存活率 外科 肿瘤科 癌症 多中心研究
作者
Makoto Yamasaki,Hiroshi Miyata,Kotaro Yamashita,Takuya Hamakawa,Koji Tanaka,Keijiro Sugimura,Tomoki Makino,Atsushi Takeno,Osamu Shiraishi,Masaaki Motoori,Yutaka Kimura,Motohiro Hirao,Kazumasa Fujitani,Toshiko Yasuda,Masahiko Yano,Hidetoshi Eguchi,Yuichiro� Doki
出处
期刊:British Journal of Cancer [Springer Nature]
卷期号:129 (1): 54-60 被引量:2
标识
DOI:10.1038/s41416-023-02286-y
摘要

We report the long-term results as primary endpoint in a multicentre randomized prospective Phase 2 trial which compared chemoradiotherapy (CRT) and triplet chemotherapy (CT) as the initial therapy for conversion surgery (CS) in T4b esophageal cancer (EC). Patients with T4b EC were randomly assigned to the CRT group or CT group as initial treatment. CS was performed if resectable after initial or secondary treatment. The primary endpoint was 2-year overall survival, analysed by intention-to-treat. The median follow-up period was 43.8 months. The 2-year survival rate was higher in the CRT group (55.1%; 95% CI: 41.1–68.3%) compared to the CT group (34.7%; 95% CI: 22.8–48.9%), although the difference was not significant (P = 0.11). Local and regional lymph node recurrence in patients undergoing R0 resection was significantly higher in the CT group compared to the CRT group (local: 30% versus 8%, respectively, P = 0.03; regional: 37% versus 8%, respectively, P = 0.002). Upfront CT was not superior to upfront CRT as induction therapy for T4b EC in terms of 2-year survival and was significantly inferior to upfront CRT in terms of local and regional control. The Japan Registry of Clinical Trials (s051180164).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
斯文败类应助杰森斯坦虎采纳,获得10
1秒前
王柯发布了新的文献求助10
2秒前
223311完成签到,获得积分10
4秒前
blind发布了新的文献求助10
4秒前
酷波er应助激昂的飞松采纳,获得10
6秒前
王睿发布了新的文献求助10
6秒前
背后新之完成签到,获得积分10
7秒前
a_hu完成签到,获得积分10
9秒前
10秒前
11秒前
11秒前
诚心傲之完成签到,获得积分10
13秒前
安寒发布了新的文献求助10
13秒前
14秒前
14秒前
思南欧完成签到,获得积分10
14秒前
晴云发布了新的文献求助10
15秒前
henry发布了新的文献求助10
16秒前
17秒前
18秒前
MA完成签到,获得积分10
19秒前
20秒前
22秒前
小海完成签到,获得积分10
22秒前
123发布了新的文献求助10
22秒前
aaaaaa发布了新的文献求助10
22秒前
彩彩发布了新的文献求助10
22秒前
Owen应助科研通管家采纳,获得10
23秒前
Shirley应助科研通管家采纳,获得10
23秒前
23秒前
小蘑菇应助科研通管家采纳,获得10
23秒前
完美世界应助科研通管家采纳,获得10
23秒前
搜集达人应助科研通管家采纳,获得10
23秒前
小蘑菇应助科研通管家采纳,获得10
23秒前
Owen应助科研通管家采纳,获得10
23秒前
今后应助科研通管家采纳,获得30
23秒前
Orange应助科研通管家采纳,获得10
23秒前
23秒前
23秒前
AURORA发布了新的文献求助10
24秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3163383
求助须知:如何正确求助?哪些是违规求助? 2814219
关于积分的说明 7903906
捐赠科研通 2473789
什么是DOI,文献DOI怎么找? 1317077
科研通“疑难数据库(出版商)”最低求助积分说明 631615
版权声明 602187