Maternal Exposure to PM 2.5 and the Risk of Congenital Heart Defects in 1.4 Million Births: A Nationwide Surveillance-Based Study

医学 优势比 后代 怀孕 逻辑回归 人口 人口学 环境卫生 儿科 内科学 遗传学 生物 社会学
作者
Xuelian Yuan,Fengchao Liang,Jun Zhu,Keyong Huang,Li Dai,Xiaohong Li,Yanping Wang,Qi Li,Xiangfeng Lu,Jianfeng Huang,Lihui Liao,Liquan Yang,Dongfeng Gu,Hanmin Liu,Fangchao Liu
出处
期刊:Circulation [Lippincott Williams & Wilkins]
卷期号:147 (7): 565-574 被引量:17
标识
DOI:10.1161/circulationaha.122.061245
摘要

Background: Evidence remains limited about the association of maternal exposure to ambient fine particulate matter (airborne particles with an aerodynamic diameter ≤2.5 µm [PM 2.5 ]) with fetal congenital heart defects (CHDs) in highly polluted regions, and few studies have focused on preconception exposure. Methods: Using a nationwide surveillance-based case-control design in China, we examined the association between maternal exposure to PM 2.5 during periconception (defined as 3 months before conception until 3 months into pregnancy) and risk of CHD in offspring. The study included 1 434 998 births involving 7335 CHDs from 2014 through 2017 on the basis of the National Population-Based Birth Defects Surveillance System, covering 30 provinces, municipalities, or municipal districts in China. We assigned maternal PM 2.5 exposure during the periconception period to each participant using satellite-based PM 2.5 concentrations at 1-km spatial resolution. Multilevel logistic regression models were used to calculate the multivariable-adjusted odds ratio and 95% CI for CHDs in offspring associated with maternal PM 2.5 exposure, and the exposure–response association was investigated using restricted cubic spline analysis. Subgroup or sensitivity analyses were conducted to identify factors that may modify the association. Results: The average maternal exposure to PM 2.5 levels across all participants was 56.51 μg/m 3 (range, 10.95 to 182.13 μg/m 3 ). For each 10 μg/m³ increase in maternal PM 2.5 exposure, the risk of CHDs in offspring was increased by 2% (odds ratio, 1.02 [95% CI, 1.00 to 1.05]), and septal defect was the most influenced subtype (odds ratio, 1.04 [95% CI, 1.01 to 1.08]). The effect of PM 2.5 on CHD risk was more pronounced during the preconception period. Mothers <35 years of age, those living in northern China, and those living in low-income areas were more susceptible to PM 2.5 exposure than their counterparts (all P <0.05). PM 2.5 exposure showed a linear association with total CHDs or specific CHD types. Conclusions: High maternal PM 2.5 exposure, especially during the preconception period, increases risk of certain types of CHD in offspring. These findings are useful for CHD prevention and highlight the public health benefits of improving air quality in China and other highly polluted regions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
上官若男应助xiaoshuai采纳,获得10
1秒前
万能图书馆应助LiuLiu采纳,获得10
1秒前
eden发布了新的文献求助10
1秒前
2秒前
DD应助中中中采纳,获得10
2秒前
2秒前
3秒前
丁昆完成签到,获得积分20
3秒前
闾丘博超发布了新的文献求助10
4秒前
4秒前
4秒前
luermei发布了新的文献求助10
4秒前
bkagyin应助Jerryluo采纳,获得10
5秒前
hui发布了新的文献求助10
5秒前
小钟发布了新的文献求助10
5秒前
莫言发布了新的文献求助10
6秒前
爆米花应助黑黑黑采纳,获得10
6秒前
lllllllll发布了新的文献求助10
7秒前
Jia77发布了新的文献求助10
7秒前
无私鹰发布了新的文献求助10
7秒前
pluto应助cjs采纳,获得10
8秒前
情殇发布了新的文献求助10
8秒前
9秒前
大威天龙发布了新的文献求助10
9秒前
10秒前
量子星尘发布了新的文献求助10
11秒前
YF发布了新的文献求助10
12秒前
12秒前
星星完成签到,获得积分20
12秒前
华仔应助王大可采纳,获得10
12秒前
12秒前
12秒前
NexusExplorer应助枫叶采纳,获得10
13秒前
小刘完成签到 ,获得积分10
13秒前
Jia77完成签到,获得积分10
14秒前
14秒前
15秒前
SYLH应助科研通管家采纳,获得10
15秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974779
求助须知:如何正确求助?哪些是违规求助? 3519193
关于积分的说明 11197417
捐赠科研通 3255311
什么是DOI,文献DOI怎么找? 1797760
邀请新用户注册赠送积分活动 877150
科研通“疑难数据库(出版商)”最低求助积分说明 806187