子宫内膜
人口
妇科
医学
生殖医学
星团(航天器)
内科学
生物
怀孕
遗传学
计算机科学
环境卫生
程序设计语言
作者
Peigen Chen,Meng Yang,Yanfang Wang,Yingchun Guo,Yun Liu,Cong Fang,Tingting Li
标识
DOI:10.1007/s10815-022-02578-x
摘要
To explore the differences between a population with premature endometrial aging and a population with normal endometrial status in young women with recurrent implantation failure (< 35 years).Systematic analysis of the endometrium transcriptome of 274 RIF women. The NMF algorithm was used for classification based on endometrial-specific aging markers in CellAge, and the endometrial receptivity, gene expression patterns, and clinical data were compared between the classifications.Two hundred forty-five young RIF women could be divided into two clusters, in which the aging gene expression pattern of cluster 2 was closer to the reference cluster. Cluster 1 was characterized by high immune activity, while cluster 2 was characterized by high metabolic activity. Combined with clinical data, cluster 2 was worse than cluster 1 in window of implantation deviation rate and endometrial receptivity.Premature aging of the endometrium exists in young women with RIF, and premature aging of the endometrium was associated with poor reproductive outcomes.
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