Cognitive Impairment After Stroke and Treatment With Fluoxetine: A Planned Analysis of the AFFINITY Randomized Controlled Trial

Strokes increase the risk of cognitive impairment and dementia, and the risk of poststroke cognitive decline does not suside with time.1 Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, display neuroprotective, and neuroregenerative properties in animal models of brain ischemia,2 raising hope that their use could lessen the detrimental effects of stroke on cognition.