化学
催化作用
曼尼希反应
组合化学
反应条件
有机化学
作者
Daokai Xiong,Zhengjie Zhang,Jing Zhang,Yurong Wang,Jianguo Yang,Zhiming Wang,Pengfei Zhang
标识
DOI:10.1002/adsc.202300073
摘要
Abstract Hexafluoroisopropanol (HFIP) has been extensively applied in organic synthesis as a versatile reaction media. However, the application of HFIP as an catalyst in organic synthesis has been rarely studied. Presented here, is the example of HFIP‐catalyzed Mannich‐type reaction between quinoxalin‐2(1 H )‐ones and difluoroenoxysilanes. The developed protocol tolerates various substituents under mild reaction conditions, providing a divergent approach to the construction of difluoro‐substituted 3,4‐dihydroquinoxalin‐2(1 H )‐ones and monofluoroquinoxalin‐2(1 H )‐ones in 51–92% yields. magnified image
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