TBHP‐Mediated Hydroxyperfluoroalkylation of Alkenes with Perfluoroalkyl Iodides to Construct β‐Perfluoroalkyl Alcohols

Abstract A three‐component strategy for the synthesis of β‐perfluoroalkyl allyl alcohols from 1,3‐dienes is developed. A diverse range of synthetically valuable β‐perfluoroalkyl allyl alcohols are obtained in moderate to high yields. Broad substrate scope and good functional group tolerance are observed. This method is also applicable to mono‐olefins and 1,3‐enynes. The control experiment results demonstrate that the hydroxyl group OH in the product comes from TBHP. In addition, the practicality and mild reaction conditions make these synthetic transformations attractive and valuable for organic synthesis.