Exposure to volatile organic compounds and mortality in US adults: A population-based prospective cohort study

全国健康与营养检查调查 环境卫生 危险系数 比例危险模型 死因 人口 医学 疾病 内科学 置信区间
作者
Xiaobing Feng,Feng Qiu,Ling Zheng,Yue Zhang,Yuji Wang,Sheng Wang,Xia Han,Bingrong Tang,Chunxiang Yan,Ruyi Liang
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:928: 172512-172512 被引量:4
标识
DOI:10.1016/j.scitotenv.2024.172512
摘要

Volatile organic compounds (VOCs) are ubiquitous in both indoor and outdoor environments. Evidence on the associations of individual and joint VOC exposure with all-cause and cause-specific mortality is limited. Measurements of 15 urinary VOC metabolites were available to estimate exposure to 12 VOCs in the National Health and Nutritional Examination Survey (NHANES) 2005–2006 and 2011–2018. The environment risk score (ERS) was calculated using LASSO regression to reflect joint exposure to VOCs. Follow-up data on death were obtained from the NHANES Public-Use Linked Mortality File through December 31, 2019. Cox proportional hazard models and restricted cubic spline models were applied to evaluate the associations of individual and joint VOC exposures with all-cause and cause-specific mortality. Population attributable fractions were calculated to assess the death burden attributable to VOC exposure. During a median follow-up of 6.17 years, 734 (8.34 %) deaths occurred among 8799 adults. Urinary metabolites of acrolein, acrylonitrile, 1,3-butadiene, and ethylbenzene/styrene were significantly associated with all-cause, cardiovascular disease (CVD), respiratory disease (RD), and cancer mortality in a linear dose-response manner. Linear and robust dose-response relationships were also observed between ERS and all-cause and cause-specific mortality. Each 1-unit increase in ERS was associated with a 33.6 %, 39.1 %, 109.8 %, and 67.8 % increase for all-cause, CVD, RD, and cancer mortality risk, respectively. Moreover, joint exposure to VOCs contributed to 17.95 % of all-cause deaths, 13.49 % of CVD deaths, 35.65 % of RD deaths, and 33.85 % of cancer deaths. Individual and joint exposure to VOCs may enhance the risk of all-cause and cause-specific mortality. Reducing exposure to VOCs may alleviate the all-cause and cause-specific death burden.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
舒心一兰发布了新的文献求助10
刚刚
科研通AI2S应助xiaofan_www采纳,获得10
刚刚
栗子发布了新的文献求助10
刚刚
刚刚
CanLiu发布了新的文献求助30
2秒前
2秒前
3秒前
3秒前
小马甲应助锥锥采纳,获得10
3秒前
Kevin给zyzhnu的求助进行了留言
4秒前
5秒前
5秒前
等待的音响完成签到,获得积分10
5秒前
牧冬云应助Wayne采纳,获得30
5秒前
7秒前
张杰发布了新的文献求助10
8秒前
李凤凤发布了新的文献求助10
9秒前
温暖翠丝关注了科研通微信公众号
9秒前
10秒前
10秒前
11秒前
11秒前
斯文败类应助积极的未来采纳,获得10
11秒前
12秒前
王同学发布了新的文献求助10
12秒前
12秒前
蔚111发布了新的文献求助10
13秒前
13秒前
阿特拉斯耸耸肩完成签到,获得积分10
13秒前
wanwan完成签到,获得积分10
14秒前
14秒前
zpf应助serendipity采纳,获得10
15秒前
CanLiu完成签到,获得积分10
15秒前
15秒前
sensensmart发布了新的文献求助10
15秒前
15秒前
Lucas应助lydz采纳,获得10
16秒前
党旭龙完成签到,获得积分20
16秒前
江辰戏发布了新的文献求助10
16秒前
畅快的友卉完成签到,获得积分10
16秒前
高分求助中
Sustainability in ’Tides Chemistry 2000
Sustainability in ’Tides Chemistry 1500
The ACS Guide to Scholarly Communication 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Photosynthesis III 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3071459
求助须知:如何正确求助?哪些是违规求助? 2725490
关于积分的说明 7489720
捐赠科研通 2372698
什么是DOI,文献DOI怎么找? 1258199
科研通“疑难数据库(出版商)”最低求助积分说明 610233
版权声明 596916