Injectable “Homing‐Like” Bioactive Short‐Fibers for Endometrial Repair and Efficient Live Births

归巢(生物学) 医学 间质细胞 不育 子宫内膜 血管生成 癌症研究 内科学 怀孕 生物 生态学 遗传学
作者
Yumeng Cao,Jia Qi,Juan Wang,Liang Chen,Yuan Wang,Yijing Long,Boyu Li,Junliang Lai,Yejie Yao,Yiwen Meng,Xiaohua Yu,Xiao‐Dong Chen,Lai Guan Ng,Xin-yu Li,Yao Lu,Xiao-Yue Cheng,Wenguo Cui,Yun Sun
出处
期刊:Advanced Science [Wiley]
卷期号:11 (20) 被引量:4
标识
DOI:10.1002/advs.202306507
摘要

Abstract The prevalence of infertility caused by endometrial defects is steadily increasing, posing a significant challenge to women's reproductive health. In this study, injectable “homing‐like” bioactive decellularized extracellular matrix short‐fibers (DEFs) of porcine skin origin are innovatively designed for endometrial and fertility restoration. The DEFs can effectively bind to endometrial cells through noncovalent dipole interactions and release bioactive growth factors in situ. In vitro, the DEFs effectively attracted endometrial cells through the “homing‐like” effect, enabling cell adhesion, spreading, and proliferation on their surface. Furthermore, the DEFs effectively facilitated the proliferation and angiogenesis of human primary endometrial stromal cells (HESCs) and human umbilical vein endothelial cells (HUVECs), and inhibited fibrosis of pretreated HESCs. In vivo, the DEFs significantly accelerated endometrial restoration, angiogenesis, and receptivity. Notably, the deposition of endometrial collagen decreased from 41.19 ± 2.16% to 14.15 ± 1.70% with DEFs treatment. Most importantly, in endometrium‐injured rats, the use of DEFs increased the live birth rate from 30% to an impressive 90%, and the number and development of live births close to normal rats. The injectable “homing‐like” bioactive DEFs system can achieve efficient live births and intrauterine injection of DEFs provides a new promising clinical strategy for endometrial factor infertility.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
搜集达人应助小心科研采纳,获得10
刚刚
1秒前
李健的小迷弟应助QAQSS采纳,获得10
1秒前
1秒前
烟花应助lisa采纳,获得10
1秒前
贾文斌完成签到,获得积分10
2秒前
2秒前
2秒前
今后应助笨笨的店员采纳,获得10
3秒前
4秒前
Qing发布了新的文献求助10
6秒前
Qiang发布了新的文献求助10
6秒前
abc_xin完成签到,获得积分10
6秒前
7秒前
小马甲应助5U采纳,获得10
7秒前
L7完成签到,获得积分10
7秒前
7秒前
lucky发布了新的文献求助10
7秒前
airsh完成签到,获得积分10
8秒前
a达完成签到,获得积分20
9秒前
9秒前
美丽映容关注了科研通微信公众号
10秒前
VVValentin完成签到,获得积分20
10秒前
11秒前
11秒前
小二郎应助docker采纳,获得10
11秒前
wanci应助不敢装睡采纳,获得10
11秒前
Lucifer完成签到,获得积分10
12秒前
a达发布了新的文献求助10
13秒前
小美酱发布了新的文献求助10
14秒前
14秒前
15秒前
情怀应助无奈子骞采纳,获得10
15秒前
Gene发布了新的文献求助10
15秒前
griffon完成签到,获得积分10
15秒前
zzzx完成签到,获得积分10
16秒前
任1220完成签到,获得积分20
16秒前
灰姑娘完成签到,获得积分10
18秒前
ooowindy发布了新的文献求助10
18秒前
niuya发布了新的文献求助10
18秒前
高分求助中
Continuum thermodynamics and material modelling 3000
Production Logging: Theoretical and Interpretive Elements 2500
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 2000
Applications of Emerging Nanomaterials and Nanotechnology 1111
Covalent Organic Frameworks 1000
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Theory of Block Polymer Self-Assembly 750
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3479266
求助须知:如何正确求助?哪些是违规求助? 3070006
关于积分的说明 9116103
捐赠科研通 2761731
什么是DOI,文献DOI怎么找? 1515477
邀请新用户注册赠送积分活动 700958
科研通“疑难数据库(出版商)”最低求助积分说明 699931