生物
胰高血糖素样肽-1
受体
兴奋剂
败血症
炎症
Toll样受体
内分泌学
胰高血糖素样肽1受体
药理学
免疫学
神经科学
生物化学
糖尿病
2型糖尿病
先天免疫系统
作者
Susanna Fang,Chi Kin Wong
标识
DOI:10.1089/dna.2024.0057
摘要
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have shown efficacy in the treatment of metabolic disease-related complications, partially attributable to their anti-inflammatory properties. However, the specific cell types and pathways involved in these effects were not fully understood. A recent study by Wong et al. demonstrated the importance of the brain GLP-1R in mediating the anti-inflammatory effects of GLP-1RAs in Toll-like receptor and sepsis-mediated inflammation. In this discussion, we review the existing literature on the action of GLP-1RAs in inflammation and explore the implications of these recent findings.
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