TME-triggered copper-coordinated engineered programmable nanogenerators for on-demand cascade-amplifying oxidative stress

The developed TME-triggered Cu II -coordinated programmable engineered spike-like nanogenerator was constructed via coordination-driven supramolecular co-assembly of the hydrophilic stabilizer-like component EB, Fenton-like agent Cu II , and H 2 O 2 generator HND, which can be employed to achieve on-demand cascade-amplifying oxidative stress.