银屑病
发病机制
免疫系统
免疫学
PI3K/AKT/mTOR通路
医学
Wnt信号通路
先天免疫系统
疾病
生物
癌症研究
信号转导
细胞生物学
病理
作者
Jiadong Yu,Qixiang Zhao,Xiaoyan Wang,Hong Zhou,Jing Hu,Linna Gu,Yawen Hu,Fanlian Zeng,Fulei Zhao,Chengcheng Yue,Pei Zhou,Guolin Li,Ya Li,Wenling Wu,Yifan Zhou,Jiong Li
标识
DOI:10.1016/j.jaut.2022.102916
摘要
Psoriasis is a common inflammatory skin disease involving interactions between keratinocytes and immune cells that significantly affects the quality of life. It is characterized by hyperproliferation and abnormal differentiation of keratinocytes and excessive infiltration of immune cells in the dermis and epidermis. The immune mechanism underlying this disease has been elucidated in the past few years. Research shows that psoriasis is regulated by the complex interactions among immune cells, such as keratinocytes, dendritic cells, T lymphocytes, neutrophils, macrophages, natural killer cells, mast cells, and other immune cells. An increasing number of signaling pathways have been found to be involved in the pathogenesis of psoriasis, which has prompted the search for new treatment targets. In the past decades, studies on the pathogenesis of psoriasis have focused on the development of targeted and highly effective therapies. In this review, we have discussed the relationship between various types of immune cells and psoriasis and summarized the major signaling pathways involved in the pathogenesis of psoriasis, including the PI3K/AKT/mTOR, JAK-STAT, JNK, and WNT pathways. In addition, we have discussed the results of the latest omics research on psoriasis and the epigenetics of the disease, which provide insights regarding its pathogenesis and therapeutic prospects; we have also summarized its treatment strategies and observations of clinical trials. In this paper, the various aspects of psoriasis are described in detail, and the limitations of the current treatment methods are emphasized. It is necessary to improve and innovate treatment methods from the molecular level of pathogenesis, and further provide new ideas for the treatment and research of psoriasis.
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