Pathogenesis, multi-omics research, and clinical treatment of psoriasis

银屑病 发病机制 免疫系统 免疫学 PI3K/AKT/mTOR通路 医学 Wnt信号通路 先天免疫系统 疾病 生物 癌症研究 信号转导 细胞生物学 病理
作者
Jiadong Yu,Qixiang Zhao,Xiaoyan Wang,Hong Zhou,Jing Hu,Linna Gu,Yawen Hu,Fanlian Zeng,Fulei Zhao,Chengcheng Yue,Pei Zhou,Guolin Li,Ya Li,Wenling Wu,Yifan Zhou,Jiong Li
出处
期刊:Journal of Autoimmunity [Elsevier]
卷期号:133: 102916-102916 被引量:37
标识
DOI:10.1016/j.jaut.2022.102916
摘要

Psoriasis is a common inflammatory skin disease involving interactions between keratinocytes and immune cells that significantly affects the quality of life. It is characterized by hyperproliferation and abnormal differentiation of keratinocytes and excessive infiltration of immune cells in the dermis and epidermis. The immune mechanism underlying this disease has been elucidated in the past few years. Research shows that psoriasis is regulated by the complex interactions among immune cells, such as keratinocytes, dendritic cells, T lymphocytes, neutrophils, macrophages, natural killer cells, mast cells, and other immune cells. An increasing number of signaling pathways have been found to be involved in the pathogenesis of psoriasis, which has prompted the search for new treatment targets. In the past decades, studies on the pathogenesis of psoriasis have focused on the development of targeted and highly effective therapies. In this review, we have discussed the relationship between various types of immune cells and psoriasis and summarized the major signaling pathways involved in the pathogenesis of psoriasis, including the PI3K/AKT/mTOR, JAK-STAT, JNK, and WNT pathways. In addition, we have discussed the results of the latest omics research on psoriasis and the epigenetics of the disease, which provide insights regarding its pathogenesis and therapeutic prospects; we have also summarized its treatment strategies and observations of clinical trials. In this paper, the various aspects of psoriasis are described in detail, and the limitations of the current treatment methods are emphasized. It is necessary to improve and innovate treatment methods from the molecular level of pathogenesis, and further provide new ideas for the treatment and research of psoriasis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
嚣张的豆豆完成签到,获得积分10
刚刚
繁荣的念双完成签到,获得积分10
1秒前
共享精神应助米九采纳,获得10
1秒前
小蘑菇应助小羊要加油采纳,获得10
2秒前
完美世界应助研友_LaV1xn采纳,获得10
3秒前
leijh123完成签到,获得积分20
4秒前
xv完成签到,获得积分10
4秒前
CGBY完成签到 ,获得积分10
5秒前
科研通AI2S应助科研通管家采纳,获得30
7秒前
orixero应助科研通管家采纳,获得10
7秒前
wanci应助科研通管家采纳,获得10
8秒前
Byby应助柚屿采纳,获得30
8秒前
8秒前
研友_VZG7GZ应助科研通管家采纳,获得10
8秒前
香蕉觅云应助科研通管家采纳,获得10
8秒前
科研通AI2S应助科研通管家采纳,获得10
8秒前
8秒前
SciGPT应助科研通管家采纳,获得10
8秒前
Mobius完成签到,获得积分10
8秒前
9秒前
11秒前
训仔完成签到,获得积分10
11秒前
12秒前
14秒前
16秒前
赘婿应助dudu采纳,获得10
16秒前
16秒前
科目三应助AmyHu采纳,获得10
17秒前
江上钓太公完成签到,获得积分10
19秒前
斯文败类应助哈哈哈哈采纳,获得10
20秒前
niumi190发布了新的文献求助20
21秒前
礽粥粥发布了新的文献求助10
21秒前
瘦瘦的睫毛膏完成签到,获得积分10
22秒前
23秒前
NexusExplorer应助caikeke采纳,获得10
24秒前
李健应助QWE采纳,获得10
25秒前
万能图书馆应助雪雪子采纳,获得10
25秒前
挽桑发布了新的文献求助10
26秒前
zly完成签到 ,获得积分10
30秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3055401
求助须知:如何正确求助?哪些是违规求助? 2712227
关于积分的说明 7430195
捐赠科研通 2357037
什么是DOI,文献DOI怎么找? 1248528
科研通“疑难数据库(出版商)”最低求助积分说明 606737
版权声明 596093