Effects of dragon fruit oligosaccharides on immunity, gut microbiome, and their metabolites in healthy adults – A randomized double-blind placebo controlled study

益生元 肠道菌群 双歧杆菌 免疫系统 微量营养素 安慰剂 生理学 乳酸菌 微生物群 肠道微生物群 拟杆菌 食品科学 生物 免疫 益生菌 医学 免疫学 细菌 生物信息学 发酵 病理 替代医学 遗传学
作者
Nattha Pansai,Preeyabhorn Detarun,Achara Chinnaworn,Pasuree Sangsupawanich,Santad Wichienchot
出处
期刊:Food Research International [Elsevier BV]
卷期号:167: 112657-112657
标识
DOI:10.1016/j.foodres.2023.112657
摘要

Healthy food has wide popularity and relates positively to health. Our previous studies have shown that dragon fruit oligosaccharides (DFO) have prebiotic activities, balancing the gut microbiota in a simulated human colon system, and are safe and stimulate the immune system in rats. The effects of DFO on immune stimulation gut microbe modulation and the correlation of gut microbiota and nutrients were investigated in a human trial. This clinical study was a randomized, double-blinded, placebo-controlled trial. The participants were 107 healthy adults, divided into 3 groups that received DFO in drinking waterdoses of 4 and 8 g/day, compared to the placebo group for 4 consecutive weeks. DFO consumption at 4 g/day increased IgA level (11.31 mg/dL or 10.95% from baseline) and 8 g/day outstandingly promoted the growth of Bifidobacterium spp. (8.41%) and Faecalibacterium (1.99%) and decreased harmful bacteria, especially, Escherichia coli (8.44%). The relationship between gut microbes and nutrient intake was explored and significant (p < 0.05) correlations between specific microbial groups and intakes of specific macro- and micronutrients were observed. The potential dose of DFO for healthy adults was established as 4 g/day for improving IgA level and 8 g/day for promoting beneficial gut microbiota.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
隐形曼青应助噜噜噜噜噜采纳,获得10
刚刚
satisusu发布了新的文献求助10
刚刚
NCS完成签到,获得积分10
刚刚
zmc完成签到,获得积分10
1秒前
小汇报发布了新的文献求助10
1秒前
快乐滑板发布了新的文献求助10
2秒前
2秒前
2秒前
NCS发布了新的文献求助10
3秒前
SYLH应助清秀的怀蕊采纳,获得10
3秒前
韦颖发布了新的文献求助10
4秒前
4秒前
4秒前
1111应助关显锋采纳,获得20
4秒前
xiaosenlinhai完成签到,获得积分10
4秒前
5秒前
6秒前
Espionage完成签到,获得积分10
6秒前
万能图书馆应助杨柳依依采纳,获得10
7秒前
罗尔与柯西完成签到,获得积分10
7秒前
完美的友蕊应助practice采纳,获得10
7秒前
CodeCraft应助年薪百万采纳,获得10
7秒前
7秒前
sunyuhao发布了新的文献求助10
9秒前
heiner发布了新的文献求助10
9秒前
9秒前
烧酒发布了新的文献求助10
10秒前
10秒前
zhang005on发布了新的文献求助10
11秒前
12秒前
12秒前
chun123发布了新的文献求助20
12秒前
13秒前
英俊的铭应助tyy采纳,获得10
13秒前
羊咩咩完成签到 ,获得积分10
14秒前
李健应助sunyuhao采纳,获得10
14秒前
文玉梅完成签到,获得积分20
14秒前
花花完成签到 ,获得积分10
15秒前
16秒前
今后应助韦颖采纳,获得10
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969513
求助须知:如何正确求助?哪些是违规求助? 3514327
关于积分的说明 11173617
捐赠科研通 3249672
什么是DOI,文献DOI怎么找? 1794973
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804836