益生元
肠道菌群
双歧杆菌
免疫系统
微量营养素
安慰剂
生理学
乳酸菌
微生物群
肠道微生物群
拟杆菌
食品科学
生物
免疫
益生菌
医学
免疫学
细菌
生物信息学
发酵
病理
替代医学
遗传学
作者
Nattha Pansai,Preeyabhorn Detarun,Achara Chinnaworn,Pasuree Sangsupawanich,Santad Wichienchot
标识
DOI:10.1016/j.foodres.2023.112657
摘要
Healthy food has wide popularity and relates positively to health. Our previous studies have shown that dragon fruit oligosaccharides (DFO) have prebiotic activities, balancing the gut microbiota in a simulated human colon system, and are safe and stimulate the immune system in rats. The effects of DFO on immune stimulation gut microbe modulation and the correlation of gut microbiota and nutrients were investigated in a human trial. This clinical study was a randomized, double-blinded, placebo-controlled trial. The participants were 107 healthy adults, divided into 3 groups that received DFO in drinking waterdoses of 4 and 8 g/day, compared to the placebo group for 4 consecutive weeks. DFO consumption at 4 g/day increased IgA level (11.31 mg/dL or 10.95% from baseline) and 8 g/day outstandingly promoted the growth of Bifidobacterium spp. (8.41%) and Faecalibacterium (1.99%) and decreased harmful bacteria, especially, Escherichia coli (8.44%). The relationship between gut microbes and nutrient intake was explored and significant (p < 0.05) correlations between specific microbial groups and intakes of specific macro- and micronutrients were observed. The potential dose of DFO for healthy adults was established as 4 g/day for improving IgA level and 8 g/day for promoting beneficial gut microbiota.
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