中性粒细胞胞外陷阱
显微镜下多血管炎
血管炎
肉芽肿伴多发性血管炎
巨细胞动脉炎
抗体
抗中性粒细胞胞浆抗体
医学
血小板
免疫学
自身抗体
动脉炎
内科学
胃肠病学
炎症
疾病
作者
Despina Michailidou,Runa Kuley,Ting Wang,Payton Hermanson,Peter C. Grayson,David Cuthbertson,Nader Khalidi,Curry L. Koening,Carol A. Langford,Carol A. McAlear,Larry W. Moreland,Christian Pagnoux,Philip Seo,Ulrich Specks,Antoine G. Sreih,Kenneth J. Warrington,Paul A. Monach,Peter A. Merkel,Christian Lood
标识
DOI:10.1016/j.clim.2023.109274
摘要
Levels of neutrophil extracellular traps (NETs) were measured in plasma of healthy controls (HC, n = 30) and patients with granulomatosis with polyangiitis (GPA, n = 123), microscopic polyangiitis (MPA, n = 61), Takayasu's arteritis (TAK, n = 58), and giant cell arteritis (GCA, n = 68), at times of remission or activity and correlated with levels of the platelet-derived thrombospondin-1 (TSP-1). Levels of NETs were elevated during active disease in patients with GPA (p < 0.0001), MPA (p = 0.0038), TAK (p < 0.0001), and GCA (p < 0.0001), and in remission for GPA, p < 0.0001, MPA, p = 0.005, TAK, p = 0.03, and GCA, p = 0.0009. All cohorts demonstrated impaired NET degradation. Patients with GPA (p = 0.0045) and MPA (p = 0.005) had anti-NET IgG antibodies. Patients with TAK had anti-histone antibodies (p < 0.01), correlating with presence of NETs. Levels of TSP-1 were increased in all patients with vasculitis, and associated with NET formation. NET formation is a common process in vasculitides. Targeting NET formation or degradation could be potential therapeutic approaches for vasculitides.
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