医学
不利影响
随机对照试验
内科学
PCSK9
药理学
临床试验
临床研究阶段
随机化
前蛋白转化酶
作者
Christie M. Ballantyne,Puja Banka,Gustavo Méndez,Raymundo Garcia,Julio Rosenstock,Anthony Rodgers,Geraldine Mendizabal,Yale Mitchel,Alberico L. Catapano
标识
DOI：10.1016/j.jacc.2023.02.018
摘要
MK-0616 demonstrated statistically significant and robust, dose-dependent placebo-adjusted reductions in LDL-C at Week 8 of up to 60.9% from baseline and was well tolerated during 8 weeks of treatment and an additional 8 weeks of follow-up. (A Study of the Efficacy and Safety of MK-0616 [Oral PCSK9 Inhibitor] in Adults With Hypercholesterolemia [MK-0616-008]; NCT05261126).
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