医学
肝细胞癌
回顾性队列研究
超声波
前瞻性队列研究
放射科
预测值
内科学
作者
Zhe Huang,Ping Zhou,Shan Shan Li,Kaiyan Li
标识
DOI:10.1186/s40644-023-00541-2
摘要
Abstract Purpose This study evaluated the performance of the contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) in patients without LI-RADS-defined hepatocellular carcinoma (HCC) risk factors (RF−). Methods Patients with LI-RADS-defined HCC risk factors (RF+) and RF− were enrolled in a retrospective study. Additionally, a prospective evaluation in the same centre was performed as a validation set. The diagnostic performances of the CEUS LI-RADS criteria in RF+ and RF− patients were compared. Results Overall, we included 873 patients in the analyses. In the retrospective study, the LI-RADS category (LR)-5 specificities for diagnosing HCC did not differ between the RF+ and RF− groups (77.5% [158/204] vs 91.6% [196/214], P = 0.369, respectively). However, the positive predictive value (PPV) of CEUS LR-5 was 95.9% (162/169) and 89.8% (158/176) in the RF+ and RF− groups, respectively ( P = 0.029). In the prospective study, the PPV of LR-5 for HCC lesions was significantly higher in the RF+ group than in the RF− group ( P = 0.030). The sensitivity and specificity did not differ between the RF+ and RF− groups ( P = 0.845 and P = 0.577, respectively). Conclusions The CEUS LR-5 criteria shows clinical value for diagnosis of HCC in patients with and without risks.
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