别孕甾酮
医学
萧条(经济学)
心情
神经活性类固醇
情绪障碍
精神科
雌激素
临床心理学
内分泌学
内科学
焦虑
受体
经济
宏观经济学
γ-氨基丁酸受体
出处
期刊:Current Opinion in Obstetrics & Gynecology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-02-07
卷期号:35 (2): 150-153
被引量:2
标识
DOI:10.1097/gco.0000000000000857
摘要
Purpose of review The purpose of this review is to provide an update on the most recent research regarding potential causes and treatments for perimenopausal depression. Recent findings Erratic estrogen fluctuations and alterations in the neurosteroid allopregnanolone are important contributors to perimenopausal mood symptoms. These hormone changes augment increased risk associated with recent stressful events, as well as early life childhood events. Perimenopausal depressions have different clinical presentations and may respond to differential treatment approaches. Summary Future research should focus on these recent findings of interindividual hormonal sensitivity, childhood trauma histories, and varying depression symptom profiles for a personalized treatment approach to perimenopausal depression.
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