Perimenopausal depression: review of recent findings and implications for future research

Purpose of review The purpose of this review is to provide an update on the most recent research regarding potential causes and treatments for perimenopausal depression. Recent findings Erratic estrogen fluctuations and alterations in the neurosteroid allopregnanolone are important contributors to perimenopausal mood symptoms. These hormone changes augment increased risk associated with recent stressful events, as well as early life childhood events. Perimenopausal depressions have different clinical presentations and may respond to differential treatment approaches. Summary Future research should focus on these recent findings of interindividual hormonal sensitivity, childhood trauma histories, and varying depression symptom profiles for a personalized treatment approach to perimenopausal depression.