背景(考古学)
癌变
癌症
计算生物学
生物
核糖核酸
癌细胞
细胞生物学
化学
神经科学
遗传学
基因
古生物学
作者
Ann Boija,Isaac Klein,Richard A. Young
出处
期刊:Cancer Cell
[Elsevier]
日期:2021-02-01
卷期号:39 (2): 174-192
被引量:171
标识
DOI:10.1016/j.ccell.2020.12.003
摘要
Summary
Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensates are membrane-less bodies, often formed by liquid-liquid phase separation, that compartmentalize protein and RNA molecules with related functions. New insights from condensate studies portend a profound transformation in our understanding of cellular dysregulation in cancer. Here we summarize key features of biomolecular condensates, note where they have been implicated—or will likely be implicated—in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensates, and discuss some of the questions that must be addressed to further advance our understanding and treatment of cancer.
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