立体中心
对映选择合成
铱
共轭体系
化学
不对称氢化
催化作用
对映体
组合化学
齿合度
光学活性
Noyori不对称加氢
有机化学
晶体结构
聚合物
作者
Bram B. C. Peters,Jira Jongcharoenkamol,Suppachai Krajangsri,Pher G. Andersson
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-12-22
卷期号:23 (1): 242-246
被引量:16
标识
DOI:10.1021/acs.orglett.0c04012
摘要
Asymmetric hydrogenation of conjugated enones is one of the most efficient and straightforward methods to prepare optically active ketones. In this study, chiral bidentate Ir–N,P complexes were utilized to access these scaffolds for ketones bearing the stereogenic center at both the α- and β-positions. Excellent enantiomeric excesses, of up to 99%, were obtained, accompanied with good to high isolated yields. Challenging dialkyl substituted substrates, which are difficult to hydrogenate with satisfactory chiral induction, were hydrogenated in a highly enantioselective fashion.
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