生物
瘦素
昼夜节律
下丘脑
能量稳态
小鼠苗条素受体
内科学
内分泌学
夜行的
受体
神经科学
肥胖
医学
遗传学
生态学
作者
Chelsea L. Faber,Jennifer D. Deem,Bao Anh Phan,Tammy P. Doan,Kayoko Ogimoto,Zaman Mirzadeh,Michael W. Schwartz,Gregory J. Morton
出处
期刊:eLife
[eLife Sciences Publications Ltd]
日期:2021-02-02
卷期号:10
被引量:38
摘要
The brain plays an essential role in driving daily rhythms of behavior and metabolism in harmony with environmental light–dark cycles. Within the brain, the dorsomedial hypothalamic nucleus (DMH) has been implicated in the integrative circadian control of feeding and energy homeostasis, but the underlying cell types are unknown. Here, we identify a role for DMH leptin receptor-expressing (DMH LepR ) neurons in this integrative control. Using a viral approach, we show that silencing neurotransmission in DMH LepR neurons in adult mice not only increases body weight and adiposity but also phase-advances diurnal rhythms of feeding and metabolism into the light cycle and abolishes the normal increase in dark-cycle locomotor activity characteristic of nocturnal rodents. Finally, DMH LepR -silenced mice fail to entrain to a restrictive change in food availability. Together, these findings identify DMH LepR neurons as critical determinants of the daily time of feeding and associated metabolic rhythms.
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